Modulation of cannabinoid signaling by amygdala α2-adrenergic system in fear conditioning
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- 作者：Mohammad Nasehia ; Nasehi@iricss.org" class="auth_mail" title="E-mail the corresponding author ; Majid Zamanparvarb ; Mohaddeseh Ebrahimi-Ghiric ; Mohammad-Reza Zarrindasta ; d ; e ; f ; g ; h ; zarinmr@ams.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACPA ; Clonidine ; Yohimbine ; Fear memory conditioning ; Mice
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：300
- 期：Complete
- 页码：114-122
- 全文大小：1792 K
文摘
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Activation of CB1 receptors by ACPA impaired contextual and auditory fear memories.
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A same result was observed with intra-BLA microinjection of Clonidine or yohimbine.
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Subthreshold dose of clonidine did not alter deficit in both memories induced by ACPA.
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Subthreshold dose of yohimbine potentiated ACPA-induced contextual memory deficit.
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BLA α2-adrenoceptors are only involved in ACPA-induced contextual memory deficit.