What can we learn from the microbial ecological interactions associated with polymicrobial diseases?

详细信息    查看全文

• 作者：J.F. Antiabong^a ; ^d ; ^{john.antiabong@flinders.edu.au" class="auth_mail} ; ^{anti0006@flinders.edu.au" class="auth_mail} ; W. Boardman^b ; ^c ; A.S. Ball^a ; ^d
• 关键词：Polymicrobial disease ; Periodontal disease ; Microbial ecology ; Molecular tools ; Anti-infective ; Vaccine
• 刊名：Veterinary Immunology and Immunopathology
• 出版年：15 March, 2014
• 年：2014
• 卷：158
• 期：1-2
• 页码：30-36
• 全文大小：836 K

文摘

Periodontal diseases in humans and animals are model polymicrobial diseases which are associated with a shift in the microbial community structure and function; there is therefore a need to investigate these diseases from a microbial ecological perspective. This review highlights three important areas of microbial ecological investigation of polymicrobial diseases and the lessons that could be learnt: (1) identification of disease-associated microbes and the implications for choice of anti-infective treatment; (2) the implications associated with vaccine design and development and (3) application of the dynamics of microbial interaction in the discovery of novel anti-infective agents. This review emphasises the need to invigorate microbial ecological approaches to the study of periodontal diseases and other polymicrobial diseases for greater understanding of the ecological interactions between and within the biotic and abiotic factors of the environment.