Complementarity of SOMAscan to LC-MS/MS and RNA-seq for quantitative profiling of human embryonic and mesenchymal stem cells
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- 作者：Anja M. Billing anb2061@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Hisham Ben Hamidane hbh2002@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Aditya M. Bhagwat adb2018@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Richard J. Cotton rjc2003@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Shaima S. Dib ssd2002@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Pankaj Kumar pankaj123@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shahina Hayat shh2026@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Neha Goswami neg2007@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Karsten Suhre kas2049@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Arash Rafii jat2021@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Johannes Graumann ; jog2030@qatar-med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ESC ; embryonic stem cells ; ESC-MSC ; embryonic stem cell-derived mesenchymal stem cells ; BM-MSC ; bone marrow-derived mesenchymal stem cells ; SOMA ; SOMAscan assay ; a trademark by SomaLogic ; Boulder CO ; RNA ; RNA sequencing ; PROT ; liquid chromatography coupled to mass spectrometry-based proteomics ; SDEs ; significant differentially expressed
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：86-97
- 全文大小：2153 K
文摘
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SOMAscan performance has been compared side by side to LC-MS/MS and RNA-seq analysis.
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Complementarity of SOMAscan to LC-MS/MS and RNA-seq improves molecular characterization of MSC.
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ESC derived MSC are potentially more suitable for treatment of neurological diseases.
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In-depth exploration of ESC and MSC CD markers and signaling molecules by SOMAscan
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