A novel cytotoxic activity of the fruit of Sorbus commixta against human lung cancer cells and isolation of the major constituents

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• 作者：Tae Kyoung Lee^a ; ¹ ; ^{charmelon8@gmail.com} ; Hyun-Soo Roh^b ; ¹ ; ^{hyunsno@naver.com} ; Jae Sik Yu^a ; ^jsyu@bu.edu ; Dong-Joo Kwon^c ; ^{kdj8731@himh.co.kr} ; Sun Young Kim^c ; ^{wiscsyk@himh.co.kr} ; Kwan-Hyuck Baek^b ; ^{khbaek@skku.edu} ; Ki Hyun Kim^a ; ^{khkim83@skku.edu}
• 关键词：Sorbus commixta ; Rosaceae ; Lung adenocarcinoma ; Cytotoxicity ; Apoptosis
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：1-7
• 全文大小：1673 K
• 卷排序：30

文摘

Sorbus commixta Hedl. (Rosaceae) is a well-known herbal tree. Its fruit, commonly called the rowanberry, is traditionally eaten for refreshment and has been used as a laxative and as a gargle for sore throats. We explored the novel pharmacological activity of the S. commixta fruit and found that its ethanolic extracts reduced the viability of human lung adenocarcinoma cells by inducing apoptotic cell death in a p53-independent manner. Column chromatographic separation of the ethanolic extract led to isolation of three main constituents, benzyl β-d-glucopyranoside, sambunigrin, and prunasin. This is the first report showing the presence of the cyanogenic glycosides, sambunigrin and prunasin, in S. commixta fruit. These findings provide experimental evidence for a novel biological activity of S. commixta fruit against human lung cancer cells and identification of the main constituents, which raise the potential of using S. commixta fruit as a functional food for tumor prevention and management.