Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
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- 作者：Marcela Montes de Oca1 ; 2 ; Rajiv Kumar1 ; 3 ; Fabian de Labastida Rivera1 ; Fiona H. Amante1 ; Meru Sheel1 ; 10 ; Rebecca J. Faleiro1 ; 4 ; Patrick T. Bunn1 ; 5 ; Shannon E. Best1 ; Lynette Beattie1 ; Susanna S. Ng1 ; 6 ; Chelsea L. Edwards1 ; 2 ; Glen M. Boyle1 ; Ric N. Price7 ; 8 ; 9 ; Nicholas M. Anstey7 ; 8 ; Jessica R. Loughland7 ; 8 ; Julie Burel1 ; Denise L. Doolan1 ; 11 ; Ashraful Haque1 ; James S. McCarthy1 ; 2 ; j.mccarthy@uq.edu.au" class="auth_mail" title="E-mail the corresponding author ; Christian R. Engwerda1 ; 12 ; chrise@qimr.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：malaria ; type I interferons ; CD4+ T cells ; immune regulation ; Tr1 cells ; Th1 cells
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：399-412
- 全文大小：2559 K
文摘
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Plasmodium falciparum-induced type I IFNs suppress Th1 cell development
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Type I IFNs promote development of parasite-specific IL-10-producing Th1 (Tr1) cells
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Chemoprophylaxis stimulates type I IFN-dependent, parasite-specific IL-10 production
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Parasite-induced IL-10 suppresses inflammatory cytokine production