Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

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• 作者：Assaf Amitai¹ ; ² ; ⁶ ; Andrew Seeber³ ; ⁴ ; ⁶ ; Susan M. Gasser³ ; ⁴ ; ⁷ ; ^{susan.gasser@fmi.ch} ; David Holcman¹ ; ⁵ ; ^{david.holcman@ens.fr}
• 关键词：chromatin dynamics ; nucleosome compaction ; polymer model ; double-strand break ; actin cytoskeleton ; microtubules ; time-lapse imaging ; DNA damage ; DNA mobility ; numerical stimulations
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1200-1214
• 全文大小：3405 K
• 卷排序：18

文摘

A robust analytical workflow for single-particle trajectories is presented β-polymer modeling predicts chromatin expansion at double-strand breaks Altered nucleosome interaction drives break extrusion from a chromatin domain Effects of local chromatin are distinct from actin-driven nuclear oscillation