Ferroxidase-Mediated Iron Oxide Biomineralization: Novel Pathways to Multifunctional Nanoparticles
详细信息 查看全文
- 作者：Kornelius Zeth
- 关键词：biomineralization ; nanobiotechnology ; ferritin ; Dps ; encapsulin
- 刊名：Trends in Biochemical Sciences
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：41
- 期：2
- 页码：190-203
- 全文大小：4336 K
文摘
Iron oxide biomineralization occurs in all living organisms and typically involves protein compartments ranging from 5 to 100 nm in size. The smallest iron-oxo particles are formed inside dodecameric Dps protein cages, while the structurally related ferritin compartments consist of twice as many identical protein subunits. The largest known compartments are encapsulins, icosahedra made of up to 180 protein subunits that harbor additional ferritin-like proteins in their interior. The formation of iron-oxo particles in all these compartments requires a series of steps including recruitment of iron, translocation, oxidation, nucleation, and storage, that are mediated by ferroxidase centers. Thus, compartmentalized iron oxide biomineralization yields uniform nanoparticles strictly determined by the sizes of the compartments, allowing customization for highly diverse nanotechnological applications.