Extracellular vesicles as new players in angiogenesis

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• 作者：Sharad Kholia^a ; Andrea Ranghino^a ; Paolo Garnieri^b ; Tatiana Lopatina^a ; Maria Chiara Deregibus^a ; Pietro Rispoli^b ; Maria Felice Brizzi^a ; Giovanni Camussi^a ; ^{giovanni.camussi@unito.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：EVs ; extracellular vesicles ; MVBs ; multivesicular bodies ; ESCRT ; exosomal sorting complex required for transport ; DCs ; dendritic cells ; lncRNA ; long non-coding RNA ; miRNA ; microRNA ; MMP ; matrix metalloproteinases ; EGFRvIII ; epidermal growth factor receptor vIII ; VEGF ; vascular endothelial factor ; VEGF-R2 ; vascular endothelial factor-receptor 2 ; FGF ; fibroblast growth factor ; EGF-R ; epidermal growth factor-receptor ; IL-3 ; interleukin-3 ; IL-6 ; interleukin-6 ; IL-8 ; interleukin-8 ; TIMP-1 and -2 ; tis
• 刊名：Vascular Pharmacology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：86
• 期：Complete
• 页码：64-70
• 全文大小：962 K

文摘

Growing evidence suggests that small vesicles actively released from cells may encapsulate transcriptional regulators and RNA molecules. Their ability to interact with neighbouring cells and/or with distant cells through biological fluids, makes them a medium through which intercellular exchange of information can happen. Recently, membrane vesicles, which include exosomes and microvesicles, gained a place amongst the vast group of angiogenic mediators. In the present review we discuss the potential relevance of these vesicles in physiological and pathological situations of angiogenesis as well as their mechanism of action.