Amplification of Adipogenic Commitment by VSTM2A

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• 作者：Blandine Secco¹ ; É ; tienne Camiré ; ¹ ; Marc-Antoine Bri&egrave ; re¹ ; Alexandre Caron¹ ; Armande Billong¹ ; Yves Gé ; linas¹ ; Anne-Marie Lemay¹ ; Kevin M. Tharp² ; Peter L. Lee³ ; Sté ; phane Gobeil⁴ ; Jean V. Guimond⁵ ; Natacha Patey⁶ ; David A. Guertin³ ; Andreas Stahl² ; É ; lie Haddad⁷ ; David Marsolais¹ ; Yohan Bossé ; ¹ ; Kivanc Birsoy⁸ ; Mathieu Laplante¹ ; ⁹ ; ^{mathieu.laplante@criucpq.ulaval.ca}
• 关键词：3T3-L1 ; adipogenesis ; adipogenic commitment ; preadipocyte ; obesity ; adipose tissue ; cell differentiation ; cell signaling
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：93-106
• 全文大小：3294 K
• 卷排序：18

文摘

VSTM2A is highly expressed and secreted by committed preadipocytes VSTM2A is expressed early during adipocyte development in vitro and in vivo VSTM2A overexpression promotes adipogenesis while its knockdown impairs this process VSTM2A amplifies BMP signaling and Pparg2 expression in preadipocytes