Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein β-CCAAT-enhancer-binding protein α activation
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- 作者：Jianghong Wu1 ; Guoyong Hu1 ; Yingying Lu1 ; Junyuan Zheng ; Jing Chen ; Xingpeng Wang ; richardwangxp@163.com" class="auth_mail" title="E-mail the corresponding author ; Yue Zeng ; zengyue1592@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP ; acute pancreatitis ; ATF6 ; activating transcription factor 6 ; BSA ; bovine serum albumin ; CCK-8 ; cholecystokinin-8 ; C/EBP ; CCAAT-enhancer-binding protein ; CHOP ; CCAAT/enhancer binding protein (C/EBP) homologous protein ; eIF2 ; αeukaryotic translation initiation factor 2α ; EMSA ; electrophoretic mobility shift assays ; ER ; endoplasmic reticulum ; GRP78 ; glucose-related peptide 78 ; H&E ; hematoxylin and eosin ; HFD ; high fat diet ; HTG ; hypertriglyceridemia ; IκB ; I kappa B ; IL-6 ; interleukin-6 ; IRE1 ; i
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：79
- 期：Complete
- 页码：181-193
- 全文大小：5120 K
文摘
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Hypertriglyceridemia aggravates acute pancreatitis with enhanced inflammatory responses in experimental acute pancreatitis model.
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ER stress is responsible for inflammatory responses in PA-stimulated pancreatic acinar cells.
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C/EBPα and C/EBPβ were activated and dependent on ER stress in PA-induced PAC injuries.
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C/EBPβ activation was responsible for inflammatory responses and C/EBPα activation in PA-stimulated PACs.