Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation
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- 作者：Soňa Jantová ; a ; Nata&scaron ; a Mrvová ; a ; b ; natasa.mrvova@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Roman Hudeca ; Já ; n Sedlá ; kc ; Miroslav Pá ; nikd ; Viktor Milatae
- 关键词：HeLa cells ; Quinolone derivative ; Cell cycle arrest ; Apoptosis ; UVA irradiation
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：35-44
- 全文大小：3444 K
文摘
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Selenadiazoloquinolone E2h is a new potent photosensitizer.
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E2h inhibited the growth of HeLa cells and induced S and G2/M arrest and apoptosis.
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UVA irradiation (dose 0.359 J cm− 2) increased derivative cytotoxicity.
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Changes in ROS level, mitochondrial potential and caspase 3 activity were found.