Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

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• 作者：Holger Garn ; PhD^a ; Sabine Bahn ; MD ; PhD^b ; Bernhard T. Baune ; MD ; PhD^c ; Elisabeth B. Binder ; MD^d ; Hans Bisgaard ; MD^e ; Talal A. Chatila ; MD ; PhD^f ; Triantafyllos Chavakis ; MD^g ; Carsten Culmsee ; PhD^h ; Udo Dannlowski ; MDⁱ ; ^m ; Steffen Gay ; MD^j ; James Gern ; MD^k ; Tari Haahtela ; MD^l ; Tilo Kircher ; MD^m ; Ulf Mü ; ller-Ladner ; MDⁿ ; Markus F. Neurath ; MD ; PhD^o ; Klaus T. Preissner ; MD^p ; Christoph Reinhardt ; PhD^q ; Graham Rook ; MD^r ; Shannon Russell ; PhD^s ; Bernd Schmeck ; MD^t ; Thaddeus Stappenbeck ; MD ; PhD^u ; Ulrich Steinhoff ; PhD^v ; Jim van Os ; MD^w ; Scott Weiss ; MD ; PhD^x ; Michael Zemlin ; MD^y ; Harald Renz ; MD^a ; ^{harald.renz@uk-gm.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chronic inflammation ; immune dysregulation ; metabolism ; environment ; epigenetics ; stress ; biodiversity
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：138
• 期：1
• 页码：47-56
• 全文大小：268 K

文摘

Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Röntgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.