Electric field as a potential directional cue in homing of bone marrow-derived mesenchymal stem cells to cutaneous wounds

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• 作者：Eliza Zimolag^a ; ^{eliza.zimolag@uj.edu.pl} ; Julia Borowczyk-Michalowska^a ; Sylwia Kedracka-Krok^b ; ^c ; Bozena Skupien-Rabian^b ; Elzbieta Karnas^a ; Slawomir Lasota^a ; Jolanta Sroka^a ; Justyna Drukala^a ; Zbigniew Madeja^a ; ^{z.madeja@uj.edu.pl}
• 关键词：A-BMAC ; anode-migrating bone marrow adherent cells ; BMAC ; bone marrow adherent cells ; C-BMAC ; cathode-migrating bone marrow adherent cells ; DC-EF ; direct current electric field ; MSC ; mesenchymal stem cells
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：267-279
• 全文大小：2805 K
• 卷排序：1864

文摘

Electric field may be a factor positioning MSCs and macrophages within a wound bed. Calcium ions are involved in macrophage electrotaxis, but not in MSC. EGFR accumulation at the cathodal side of MSCs does not initiate electrotaxis. Initial cell response to EF is very dynamic and occurs within < 1 min.