Impaired Visual Fixation at the Age of 2聽Years in Children Born Before the Twenty-Eighth Week of Gestation. Antecedents and Correlates in the Multicenter ELGAN Study

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• 作者：Anuradha Phadke ; MD^a ; Michael E. Msall ; MD^b ; Patrick Droste ; MD^c ; Elizabeth N. Allred ; MS^d ; Thomas Michael O'Shea ; MD^e ; Karl Kuban ; MD^f ; Olaf Dammann ; MD^g ; ^h ; Alan Leviton ; MD^d ; ^{alan.leviton@childrens.harvard.edu" class="auth_mail} ; on behalf of the ELGAN Study Investigators
• 关键词：retinopathy of prematurity ; preterm newborn ; brain ; developmental disabilities
• 刊名：Pediatric Neurology
• 出版年：July 2014
• 年：2014
• 卷：51
• 期：1
• 页码：36-42
• 全文大小：233 K

文摘

Very little is known about the prevalence, antecedents, and correlates of impaired visual fixation in former very preterm newborns.

Methods

In the multicenter ELGAN study sample of 1057 infants born before the twenty-eighth week of gestation who had a developmental assessment at 2 years corrected age, we identified 73 who were unable to follow an object across the midline. We compared them to the 984 infants who could follow an object across the midline.

Results

In this sample of very preterm newborns, those who had impaired visual fixation were much more likely than those without impaired visual fixation to have been born after the shortest of gestations (odds ratio, 3.2; 99% confidence interval, 1.4-7.5) and exposed to maternal aspirin (odds ratio, 5.2; 99% confidence interval, 2.2-12). They were also more likely than their peers to have had prethreshold retinopathy of prematurity (odds ratio, 4.1; 99% confidence interval, 1.8-9.0). At age 2 years, the children with impaired fixation were more likely than others to be unable to walk (even with assistance) (odds ratio, 7.5; 99% confidence interval, 2.2-26) and have a Mental Development Index more than three standard deviations below the mean of a normative sample (odds ratio, 3.6; 99% confidence interval, 1.4-8.2).

Conclusion

Risk factors for brain and retinal damages, such as very low gestational age, appear to be risk factors for impaired visual fixation. This inference is further supported by the co-occurrence at age 2 years of impaired visual fixation, inability to walk, and a very low Mental Development Index.