Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus

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• 作者：Patricia H. Gallego ; Neil Shephard ; Max K. Bulsara ; Frank M. van Bockxmeer ; Brenda L. Powell ; John P. Beilby ; Gillian Arscott ; Michael Le Page ; Lyle J. Palmer ; Elizabeth A. Davis ; Timothy W. Jones ; Ca
• 关键词：Albumin excretion rate ; Microalbuminuria ; Type 1 diabetes mellitus ; Renin– ; angiotensin system ; Nephropathy
• 刊名：Journal of Diabetes and its Complications
• 出版年：2008
• 出版时间：May-June 2008
• 年：2008
• 卷：22
• 期：3
• 页码：191-198
• 全文大小：189 K

文摘

We examined genetic polymorphisms in the renin–angiotensin system (RAS) coding for angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) for angiotensinogen (AGT) M235T and angiotensin II receptor type 1 (AGTR1) A1166C as predictors for the development of microalbuminuria (MA) in children with type 1 diabetes mellitus (T1DM).