NPT088 reduces both amyloid-β and tau pathologies in transgenic mice
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- 作者：Jonathan M. Levensona ; jlevenson@neurophage.com" class="auth_mail" title="E-mail the corresponding author ; Sally Schroetera ; Jenna C. Carrolla ; Valerie Cullena ; Eva Aspa ; Ming Proschitskya ; Charlotte H.-Y. Chunga ; Sharon Gileada ; Muhammad Nadeemb ; 1 ; Hemraj B. Dodiyab ; Shadiyat Shoagab ; Elliott J. Mufsonb ; 1 ; Haim Tsuberya ; Rajaraman Krishnana ; Jason Wrighta ; Beka Solomonc ; Richard Fishera ; Kimberley S. Gannona
- 关键词：GAIM ; General amyloid interaction motif ; Novel object recognition ; Spontaneous alternation ; Limb clasping ; Thioflavin S ; Brain weight ; Cerebrospinal fluid ; Phospho-tau
- 刊名：Alzheimer's & Dementia: Translational Research & Clinical Interventions
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：2
- 期：3
- 页码：141-155
- 全文大小：2979 K
文摘
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NPT088 binds to and remodels misfolded aggregates of both Aβ and tau.
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Systemic administration of NPT088 improves cognition, reduces levels of Aβ42 and lowers fibrillar Aβ plaque in aged Tg2576 hAPP mice.
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NPT088 does not increase levels of Aβ in CSF.
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Systemic administration of NPT088 improves cognition, improves motor function, reduces phospho-tau and reduces brain atrophy in rTg4510 tau mice.