Scope, limitations and classification of lactamases
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- 作者：Zeinab Assafa ; b ; Kurt Faberb ; Mé ; lanie Hallb ; melanie.hall@uni-graz.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vince lactam ; Lactamase ; Amidase ; Enantioselective ; Enzyme ; Hydrolysis ; Kinetic resolution
- 刊名：Journal of Biotechnology
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：235
- 期：Complete
- 页码：11-23
- 全文大小：3839 K
文摘
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Lactamase activity on 5- and 6-membered ring lactams is restricted to bicyclic Vince lactam derivatives.
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Enzymes with enantiocomplementary activities belong to two distinct enzyme classes.
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Protein structure and/or sequence analysis allows prediction of enantiopreference.
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Important industrial applications of kinetic resolution of Vince lactam derivatives are presented.