Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus
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- 作者：Nishank Bhalla ; Chengqun Sun ; L.K. Metthew Lam ; Christina L. Gardner ; Kate D. Ryman ; William B. Klimstra ; Klimstra@pitt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alphavirus ; Venezuelan equine encephalitis virus ; Eastern equine encephalitis virus ; Sindbis virus ; Chikungunya virus ; Nonstructural protein 2 ; Transcription shutoff ; Translation shutoff ; Antiviral state resistance ; Interferon
- 刊名：Virology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：496
- 期：Complete
- 页码：147-165
- 全文大小：3843 K
文摘
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VEEV is the alphavirus most resistant to the IFN-induced antiviral state.
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Transcription and translation shutoff are independently mediated viral activities.
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VEEV nsP2 shuts off host translation but not transcription.
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VEEV nsP2, but not SINV nsP2, shuts of host translation in IFN-primed cells.
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NsP2-mediated translation shutoff is critical for the resistance phenotype of VEEV.