Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses
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- 作者：Amber B. Ricoa ; amber.rico@colostate.edu" class="auth_mail" title="E-mail the corresponding author ; Aaron T. Phillipsa ; 1 ; Tony Schountza ; Donald L. Jarvisb ; Ronald B. Tjalkensc ; Ann M. Powersd ; Ken E. Olsona
- 关键词：Alphavirus ; Bioluminescence ; Eastern equine encephalitis virus ; In vivo imaging ; Subunit vaccine ; Togaviridae ; Venezuelan equine encephalitis virus ; Western equine encephalitis virus
- 刊名：Virology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：499
- 期：Complete
- 页码：30-39
- 全文大小：2335 K
文摘
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We developed a LANAC-based vaccine containing multiple alphavirus E1 antigens.
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The LANAC-based vaccine did not diminish antibody responses to each E1 antigen.
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LANAC VEEV E1+WEEV E1 vaccination protected mice against NWAs.
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Passive transfer of VEEV E1+WEEV E1 immune sera conferred protection to NWAs.