Research progress on the reproductive and non-reproductive endocrine tumors by estrogen-related receptors
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- 作者：Zhixiang Xu ; Jun Liu ; Lipeng Gu ; Xiaodong Ma ; Bin Huang ; Xuejun Pan ; xjpan@kmust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Estrogen receptor ; Estrogen-related receptors ; Reproductive endocrine tumors ; Non-reproductive endocrine tumors ; tumor prevention
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：22-30
- 全文大小：1449 K
文摘
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ERRs share the same substantial homology with classical nuclear estrogen receptors.
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ERRs play an important role in cancer tumorigenesis and development.
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ERRs variant isoforms expression levels were different varied between cells within different tissues, and showed distinct functions in different tumors.
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ERRα overexpression and ERRβ/γ overexpression were related to cells proliferation and suppression, respectively.