Periconones B-E, new meroterpenoids from endophytic fungus Periconia sp.

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• 作者：Ji-Mei Liu^a ; ¹ ; De-Wu Zhang^a ; ^b ; ¹ ; Min Zhang^a ; Ri-Dao Chen^a ; Zheng Yan^a ; Jian-Yuan Zhao^b ; Jin-Lian Zhao^a ; Nan Wang^a ; Jun-Gui Dai^a ; ^{jgdai@imm.ac.cn}
• 关键词：Meroterpenoids ; Periconia ; Endophytic fungus ; Annona muricata ; Periconone
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：248-252
• 全文大小：798 K
• 卷排序：28

文摘

Periconones B–E (1–4), four new polyketide–terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were established by extensive spectroscopic data analysis and electronic circular dichroism (ECD). Compound 4 exhibited in vitro cytotoxic activity against the human MCF-7 tumor cell line with an IC50 value of 4.2 μmol/L, and compound 1 displayed anti-HIV activity with an IC50 value of 18.0 μmol/L.