Mitral valve endothelial cells secrete osteoprotegerin during endothelial mesenchymal transition
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- 作者：Paola Songiaa ; b ; Emanuela Branchettic ; Alessandro Parolarid ; e ; Veronika Myasoedovaa ; Giovanni Ferraric ; Francesco Alamannia ; f ; Elena Tremolia ; Paolo Poggioa ; Paolo.Poggio@ccfm.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Circulating marker ; Endothelial to mesenchymal transition ; Mitral valve prolapse ; Valve endothelial cells ; Valve interstitial cells
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：48-57
- 全文大小：1343 K
文摘
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MVP leaflets showed higher levels of OPG than control subjects.
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Endothelial-to-mesenchymal transition increase OPG production and secretion.
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OPG induced endothelial cell migration and reactive oxygen species production.
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OPG induced VIC proliferation and collagen production.
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OPG plasma levels were highly increased in MVP patients than control subjects.