Differential effect of hypoxia on early endothelial-mesenchymal transition response to transforming growth beta isoforms 1 and 2
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- 作者：Meghan Doerr1 ; Jodi Morrison ; Lindsay Bergeron2 ; Brenda L. Coomber ; Alicia Viloria-Petit ; aviloria@uoguelph.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transforming growth factor beta ; Endothelial&ndash ; mesenchymal transition ; Hypoxia ; Snail ; Angiogenesis ; Endothelial cell sprouting
- 刊名：Microvascular Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：48-63
- 全文大小：2447 K
文摘
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Both TGFß1 and TGFß2 isoforms induce early EndoMT under normoxia and hypoxia.
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During this early EndoMT there is a higher ratio of Snail/Slug nuclear accumulation.
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Both TGFß1 and TGFß2 significantly reduce nuclear levels of Zeb2 under hypoxia.
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Hypoxia only enhances nuclear accumulation of phosho-Smad2 in response to TGFß1.
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In hypoxia, Snail facilitates cord formation in the presence of TGFß2 but not of TGFß1.