SP1 and USF differentially regulate ADAMTS1 gene expression under normoxic and hypoxic conditions in hepatoma cells
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- 作者：Sumeyye Aydogan Turkoglu ; Feray Kockar ; fkockar@balikesir.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADAMTS1 ; a disintegrin and metalloproteinase with thrombospondin motifs 1 ; ARPE ; human retinal pigment epithelial cell ; B2M ; human β-2 microglobulin ; C/EBPα ; CCAAT enhancer binding protein ; DU145 ; human prostate cancer cell line ; ECM ; extracellular matrix ; HCC ; Hepatocellular carcinoma ; HDAC ; histone deacetylase ; HEP3B ; human hepatoma cells ; HIF1 ; hypoxia inducible factor ; HMEC ; human mammary epithelial cell ; HPAEC ; human pulmonary artery endothelial cell ; HRE ; hypoxia response element ; HT-29 ; h
- 刊名：Gene
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：575
- 期：1
- 页码：48-57
- 全文大小：1374 K
文摘
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ADAMTS1 mRNA and protein level were upregulated in hepatoma cells at the hypoxic condition.
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Human ADAMTS1 promoter activity in hepatoma cells was repressed by SP1 and USF1 in normoxic condition.
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SP1 and USF led to the increase of ADAMTS1 gene expressions in hypoxic condition.
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C/EBPα is not involved in the regulation of human ADAMTS1 promoter in hepatoma cells.