The Chromogranin A-derived sympathomimetic serpinin depresses myocardial performance in teleost and amphibian hearts

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• 作者：S. Imbrogno^a ; ¹ ; ^{sandra.imbrogno@unical.it} ; R. Mazza^a ; ¹ ; C. Pugliese^a ; M. Filice^a ; T. Angelone^a ; Y.P. Loh^b ; B. Tota^a ; M.C. Cerra^a
• 关键词：β-ARs ; β-adrenergic receptors ; BSA ; bovine serum albumin ; CAs ; catecholamines ; CgA ; Chromogranin A ; CO ; cardiac output ; CST ; Catestatin ; ET-1 ; Endothelin-1 ; ETAR ; ET-1 type A receptors ; ETBR ; ET-1 type B receptors ; GC ; guanylyl cyclase ; HR ; heart rate ; NO ; Nitric Oxide ; NOS ; Nitric Oxide Synthase ; pAkt ; phospho-Akt ; peNOS ; phospho-eNOS ; pGlu-Serp ; pyroglutamate serpinine ; PI3K ; PI3kinase ; PKA ; cAMP-dependent kinase ; PKG ; protein kinase G ; PTx ; pertussis toxin ; Serp ; serpinin ; SV ; stroke volume
• 刊名：General and Comparative Endocrinology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：240
• 期：Complete
• 页码：1-9
• 全文大小：1019 K
• 卷排序：240

文摘

Serpinin peptides decrease myocardial performance in eel, goldfish and frog. Serpinin-elicited inotropism is mediated by a NOS/NO-dependent pathway. Serpinin-induced cardioinhibition involves β3-AR (goldfish) and ET-1R (frog).