Inhibitory effect of fentanyl citrate on the release of endothlin-1 induced by bradykinin in melanoma cells

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• 作者：Tsugunobu Andoh^a ; ^{andoht@pha.u-toyama.ac.jp} ; Akira Shinohara^a ; Yasushi Kuraishi^b
• 关键词：Bradykinin ; Endothelin-1 ; μ-Opioid receptors ; Kinin B2 receptors ; Fentanyl citrate
• 刊名：Pharmacological Reports
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：69
• 期：1
• 页码：139-142
• 全文大小：646 K
• 卷排序：69

文摘

Bradykinin (BK) induced endothlin-1 (ET-1) secretion in B16-BL6 melanoma cells. Fentanyl inhibited BK-induced ET-1 secretion in B16-BL6 cells. The action of fentanyl was attenuated by naloxone methiodide. B16-BL6 cells expressed ET-1, kinin B2 receptors, and μ-opioid receptors (MOR). The results suggest that fentanyl regulates BK-induced ET-1 secretion through MOR.