Probiotic potential of Lactobacillus paracasei FM-LP-4 isolated from Xinjiang camel milk yoghurt

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• 作者：Ying Wang^a ; ^b ; Jianzhong Zhou^b ; Xiudong Xia^b ; Yancun Zhao^b ; Weilan Shao^a ; ^{weilanshao@126.com" class="auth_mail" title="E-mail the corresponding author}
• 刊名：International Dairy Journal
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：62
• 期：Complete
• 页码：28-34
• 全文大小：1175 K

文摘

Fifty three probiotic lactic acid bacteria (LAB) strains with high anti-oxidative activity from Xinjiang camel milk yoghurt were screened and identified. Four strains showed higher 2,2-diphenyl-1-picrylhydrazyl scavenging activity and reducing power than the reference strain Lactobacillus rhamnosus GG (ATCC53103) with strain FM-LP-4, identified as Lactobacillus paracasei by 16S rDNA nucleotide sequencing, showing the highest. Strain FM-LP-4 also showed higher stress tolerance properties (acidity, bile, and osmotic pressure) and adhesion properties than L. rhamnosus GG. The in vivo antioxidant activity of FM-LP-4 was further assayed in d-galactose-induced oxidative damaged mice. Administration of FM-LP-4 significantly enhanced the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and inhibited the biosynthesis of malondialdehyde (MDA) and protein carbonyl in a dose-dependent manner. Additionally, FM-LP-4 strain could significantly decrease the endotoxin level in the serum of mice. Overall, strain FM-LP-4 is a promising probiotic candidate for preparations of functional foods and antioxidant supplements.