Long-Term Space Flight Simulation Reveals Infradian Rhythmicity in Human Na⁺ Balance

详细信息    查看全文

• 作者：Natalia Rakova¹ ; ⁵ ; ⁹ ; ¹¹ ; Kathrin Jü ; ttner¹ ; ¹¹ ; Anke Dahlmann² ; Agnes Schrö ; der¹ ; Peter Linz¹ ; Christoph Kopp² ; Manfred Rauh³ ; Ulrike Goller¹ ; Luis Beck⁶ ; Alexander Agureev⁵ ; Galina Vassilieva⁵ ; Liubov Lenkova⁵ ; Bernd Johannes⁶ ; Peter Wabel⁷ ; Ulrich Moissl⁷ ; Jö ; rg Vienken⁷ ; Rupert Gerzer⁶ ; Kai-Uwe Eckardt² ; Dominik N. Mü ; ller⁴ ; ⁹ ; Karl Kirsch⁸ ; Boris Morukov⁵ ; Friedrich C. Luft⁹ ; ¹⁰ ; Jens Titze¹ ; ² ; ¹⁰ ; ^{jens.m.titze@vanderbilt.edu}
• 刊名：Cell Metabolism
• 出版年：2013
• 出版时间：8 January, 2013
• 年：2013
• 卷：17
• 期：1
• 页码：125-131
• 全文大小：1440 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Summary

The steady-state concept of Na⁺ homeostasis, based on short-term investigations of responses to high salt intake, maintains that dietary Na⁺ is rapidly eliminated into urine, thereby achieving constant total-body Na⁺ and water content. We introduced the reverse experimental approach by fixing salt intake of men participating in space flight simulations at 12 g, 9 g, and 6 g/day for months and tested for the?predicted constancy in urinary excretion and total-body Na⁺ content. At constant salt intake, daily?Na⁺ excretion exhibited aldosterone-dependent, weekly (circaseptan) rhythms, resulting in periodic Na⁺ storage. Changes in total-body Na⁺ (¡À200-400?mmol) exhibited longer infradian rhythm periods (about monthly and longer period lengths) without parallel changes in body weight and extracellular water and were directly related to urinary aldosterone excretion and inversely to urinary cortisol, suggesting rhythmic hormonal control. Our findings define rhythmic Na⁺ excretory and retention patterns independent of blood pressure or body water, which occur independent of salt intake.