Proteomic characterization of peroxisome proliferator-activated receptor-γ (PPARγ) overexpressing or silenced colorectal cancer cells unveils a novel protein network associated with an aggressive phenotype
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- 作者：Maria Rita Milonea ; 1 ; Biagio Puccia ; 1 ; Tommaso Colangeloc ; Rita Lombardia ; Federica Iannellia ; Vittorio Colantuonic ; Lina Sabatinoc ; sabatino@unisannio.it" class="auth_mail" title="E-mail the corresponding author ; Alfredo Budillona ; b ; a.budillon@istitutotumori.na.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Peroxisome proliferator-activated receptor gamma ; Colorectal cancer ; Proteomics ; Ingenuity pathway analysis ; 2-D DIGE ; Mass spectrometry
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：10
- 期：8
- 页码：1344-1362
- 全文大小：3303 K
文摘
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PPARγ-overexpressing/silenced colorectal cancer (CRC) cells are studied by proteomics.
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The differentially expressed proteins are part of novel PPARγ signaling pathways.
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Ezrin, LaminA/C, α-enolase, prohibitin and RuvBlike2 strongly correlate with PPARγ.
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These proteins correlate with tumor expression in publicly available CRC dataset.