Atheroprotective role of Caveolin-1 and eNOS in an innovative transplantation model is mainly mediated by local effects
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- 作者：Johannes Mierke ; johannes.mierke@mailbox.tu-dresden.de ; Marian Christoph ; Christian Pfluecke ; Stefanie Jellinghaus ; Carsten Wunderlich ; Ruth H. Strasser ; Karim Ibrahim ; David M. Poitz
- 关键词：Caveolin-1 ; Endothelial NO synthase ; Atherosclerosis ; Intima formation ; Restenosis ; Transplantation
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：1863
- 期：2
- 页码：529-536
- 全文大小：1571 K
- 卷排序：1863
文摘
Transplantation of a denuded aorta into carotid artery leads to plaque formation. Caveolin-1 knockout leads to increased plaque formation. Additional knockout of eNOS in Cav1−/− aortae reduces plaque formation. Plaque formation is due rather to local than systemic effects.