Antidiarrhoeal activity of ethanol and aqueous extracts of Carum copticum seeds in experimental rats

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• 作者：G Balaji^a ; M Chalamaiah^b ; B Ramesh^c ; ^{rammygp@gmail.com} ; Y Amarnath Reddy^d
• 关键词：Carum copticum seed extracts ; Antidiarrhoeal activity ; Castor oil induced diarrhoea ; Enteropooling method ; Gastrointestinal transit
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2012
• 出版时间：February, 2012
• 年：2012
• 卷：2
• 期：2_supp_S
• 页码：S1151-S1155
• 全文大小：1K

文摘

Objective

To investigate the antidiarrhoeal activity of 95 % total alcoholic extract (TAE) and total aqueous extract (TAQ) of Carum copticum (C. copticum) seeds.

Methods

Antidiarrhoeal activity of C. copticum seed extracts at a dose of 100 mg/kg BW was evaluated using experimentally induced castor oil diarrhoea, gastrointestinal transit of charcoal meal and enteropooling activity in male wistar rats and compared to standard drugs.

Results

At a dose of 100 mg/Kg BW (TAQ and TAE) significantly decreased the diarrhoeal droppings in castor oil induced diarrhoea, the mean distance travelled by charcoal meal showed a significant reduction in the secretion of gastrointestinal fluid accumulation by 39.90 % to 50.70 % . C. copticum extracts on castor oil induced fluid accumulation showed a greater inhibitory effect on Na⁺ levels than on K⁺ concentrations.

Conclusions

These results suggest that C. copticum seed extracts could be used for the treatment of diarrhoea.