Studies on the anti-diarrheal properties of leaf extract of Desmodium puchellum

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• 作者：Md. Khalilur Rahman ; Soumitra Barua ; Md. Fokhrul Islam ; Md. Rafikul Islam ; Mohammed Abu Sayeed ; Mst. Shahnaj Parvin ; Md. Ekramul Islam
• 关键词：Antidiarrhea ; Thrombolysis ; Desmodium puchellum ; Loperamide
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：3
• 期：8
• 页码：639-643
• 全文大小：327 K

文摘

Objective

To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract of Desmodium puchellum (Family: Fabaceae) leaves.

Methods

The extract was evaluated for castor oil-induced diarrhea and enteropooling as well as intestinal motility in rats. Both of the extracts were given to the rats at 200 mg/kg orally. Loperamide was used as a standard drug for diarrhea.

Results

The diarrheal severity was reduced significantly (P<0.05) by methanol and petroleum ether extracts by 31.95 % and 28.33 % , respectively, whereas 54.75 % inhibition was found for standard drug loperamide at 5 mg/kg. The two extracts also significantly (P<0.05) reduced the intestinal volume in case of castor oil induced enteropooling.

Conclusions

It is concluded that both fractions contain some biologically active ingredients that are active for anti-diarrheal actions whereas methanol fraction has better potential.