A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis
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- 作者：Patrick McMillen1 ; Veena Chatti1 ; Dö ; rthe Jü ; lich1 ; Scott A. Holley1 ; scott.holley@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：somite ; morphogenesis ; cadherin 2 ; integrin α5 ; EphA4 ; ephrinB2a ; cytoskeletal contractility ; zebrafish ; fibronectin ; segmentation ; boundary formation ; differential adhesion
- 刊名：Current Biology
- 出版年：2016
- 出版时间：22 February 2016
- 年：2016
- 卷：26
- 期：4
- 页码：542-549
- 全文大小：3872 K
文摘
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A gradient of cadherin 2 stability is observed in each somite
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Cadherin 2 promotes epithelialization of the posterior somite
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Differential cadherin 2 levels induce integrin α5 activation and border formation
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Cadherin 2 stimulates boundary ECM assembly by increasing tissue stiffness