EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis
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- 作者：Hongyu Luoa ; 1 ; Bieke Brouxa ; b ; c ; 1 ; Xuehai Wanga ; Yan Hua ; Soufiane Ghannama ; b ; Wei Jina ; Catherine Larochellea ; b ; Alexandre Prata ; b ; a.prat@umontreal.ca" class="auth_mail" title="E-mail the corresponding author ; Jiangping Wua ; d ; jianping.wu@umontreal.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：BBB ; blood brain barrier ; BBB-EC ; blood brain barrier endothelial cell ; CNS ; central nervous system ; dKO ; double knock out ; EAE ; experimental autoimmune encephalomyelitis ; EFN ; ephrin ; EPH ; EPH receptor ; MOG ; myelin oligodendrocyte glycoprotein
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：292-306
- 全文大小：2527 K
文摘
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EFNB1/B2 dKO mice exhibit lower clinical scores after MOG35–55 induced EAE.
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EFNB1/B2 dKO T cells show impaired Th17 differentiation and migration.
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EFNB1/B2 are expressed on human Th17 cells in vitro and on T cells in MS lesions.
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EFNB1/B2 reverse signaling increases Th17 migration through BBB endothelial cells.