Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

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• 作者：Mathilde Latil¹ ; ⁶ ; Dany Nassar¹ ; ⁶ ; Benjamin Beck¹ ; Soufiane Boumahdi¹ ; Li Wang² ; Audrey Brisebarre¹ ; Christine Dubois¹ ; Erwin Nkusi¹ ; Sandrine Lenglez¹ ; Agnieszka Checinska¹ ; Alizé ; e Vercauteren Drubbel¹ ; Michael Devos³ ; ⁴ ; Wim Declercq³ ; ⁴ ; Rui Yi² ; Cé ; dric Blanpain¹ ; ⁵ ; ⁷ ; ^{cedric.blanpain@ulb.ac.be}
• 关键词：skin cancer ; cancer cell of origin ; EMT ; epigenetic ; gene regulatory network ; cancer cell plasticity ; tumor heterogeneity ; cellular reprogramming ; transcription factors
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：20
• 期：2
• 页码：191-204.e5
• 全文大小：5815 K
• 卷排序：20

文摘

The cancer cell of origin controls EMT Transcriptional priming of EMT occurs in the cancer cell of origin Epigenetic priming of EMT occurs in the cancer cell of origin p63 restricts EMT in the cancer cell of origin