Experience-Dependent Equilibration of AMPAR-Mediated Synaptic Transmission during the Critical Period

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• 作者：Kyung-Seok Han¹ ; Samuel F. Cooke¹ ; ² ; Weifeng Xu¹ ; ³ ; ^{weifeng@mit.edu}
• 关键词：active synapse ; silent synapse ; elimination ; calmodulin ; NRGN ; maturation ; schizophrenia ; neurodegeneration ; Alzheimer&rsquo ; s disease ; connectivity
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：892-904
• 全文大小：3260 K
• 卷排序：18

文摘

AMPAR-mediated synaptic transmission remains at equilibrium during the critical period Ng is required for the maintenance of AMPAR-mediated synaptic transmission AMPAR-silent synapse conversion and synapse elimination equilibrate synaptic responses Ng coordinates these two experience-dependent processes for circuit optimization