Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: Defining optimal imaging parameters

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• 作者：Catharina M.L. Zegers ; Wouter van Elmpt ; Roel Wierts ; Bart Reymen ; Hoda Sharifi ; Michel C. 脰llers ; Frank Hoebers ; Esther G.C. Troost ; Rinus W ; ers ; Angela van Baardwijk ; Boudewijn Brans ; Jonas Eriksson ; Bert Windhorst ; Felix M. Mottaghy ; Dirk De Ruysscher ; Philippe Lambin
• 关键词：NSCLC ; Imaging ; Hypoxia ; PET ; HX4
• 刊名：Radiotherapy and Oncology
• 出版年：October, 2013
• 年：2013
• 卷：109
• 期：1
• 页码：58-64
• 全文大小：1043 K

文摘

Background and purpose

[¹⁸F]HX4 is a promising hypoxia PET-tracer. Uptake, spatio-temporal stability and optimal acquisition parameters for [¹⁸F]HX4 PET imaging were evaluated in non-small cell lung cancer (NSCLC) patients.

Materials and methods

[¹⁸F]HX4 PET/CT images of 15 NSCLC patients were acquired 2 h and 4 h after injection (p.i.). Maximum standardized-uptake-value (SUV_max), tumor-to-blood-ratio (TBR_max), hypoxic fraction (HF) and contrast-to-noise-ratio (CNR) were determined for all lesions. To evaluate spatio-temporal stability, DICE-similarity and Pearson correlation coefficients were calculated. Optimal acquisition-duration was assessed by comparing 30, 20, 10 and 5 min acquisitions.

Results

Considerable uptake (TBR >1.4) was observed in 18/25 target lesions. TBR_max increased significantly from 2 h (1.6 卤 0.3) to 4 h p.i. (2.0 卤 0.6). Uptake patterns at 2 h and 4 h p.i. showed a strong correlation (R = 0.77 卤 0.10) with a DICE similarity coefficient of 0.69 卤 0.08 for the 30% highest uptake volume. Reducing acquisition-time resulted in significant changes in SUV_max and CNR. TBR_max and HF were only affected for scan-times of 5 min.

Conclusions

The majority of NSCLC lesions showed considerable [¹⁸F]HX4 uptake. The heterogeneous uptake pattern was stable between 2 h and 4 h p.i. [¹⁸F]HX4 PET imaging at 4 h p.i. is superior to 2 h p.i. to reach highest contrast. Acquisition time may be reduced to 10 min without significant effects on TBR_max and HF.