Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IκBα

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• 作者：Tapan Kumar Singh Nayak ; Neeraja P. Alamuru-Yellapragada ; Kishore V.L. Parsa ; ^{kishorep@drils.org}
• 关键词：USP12 ; LPS ; Macrophages ; Inflammation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：69-74
• 全文大小：816 K
• 卷排序：483

文摘

USP12 levels are significantly altered in LPS stimulated macrophages. USP12 is required for LPS induced iNOS and IL6 expression. USP12 is crucial for LPS induced phosphorylation of IκBα, ERK1/2, p38.