Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts
详细信息 查看全文
- 作者：Xiaomin Xia ; Juanli Fu ; Xiufang Song ; Qiong Shi ; Chuanyang Su ; Erqun Song ; Yang Song ; songyangwenrong@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; ysong@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALT ; alanine transaminase ; AST ; aspartate transaminase ; CAT ; catalase ; CDNB ; 1-chloro-2 ; 4-dinitrobenzene ; COX-2 ; cyclooxygenase-2 ; DAB ; 3 ; 3&rsquo ; -diaminobenzidine ; DCFH-DA ; 2&rsquo ; 7&rsquo ; -dichlorodihydrofluorescein diacetate ; d-GalN ; D-galactosamine ; ERK ; extracellular signal-regulated kinase ; FHF ; fulminant hepatic failure ; GPx ; glutathione peroxidase ; IKK ; inhibitor of nuclear factor kappa-B kinase ; IL-1 ; interleukin-1 ; IκB ; inhibitor of NF-κB ; iNOS ; inducible nitric oxide synthase ; IRF
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：522-532
- 全文大小：9481 K
文摘
- •
NHDC attenuates d-GalN/LPS-induced fulminant hepatic failure.
- •
NHDC inhibits LPS-induced myeloid differentiation factor 88 dependent signaling.
- •
NHDC inhibits LPS-induced TIR-containing adapter molecule dependent signaling.
- •
NHDC inhibits LPS-induced the translocation of TLR4 into lipid raft domains.
- •
These results implied a new application of NHDC as a hepatoprotective agent.