Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells
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- 作者：Swetha Rudraiaha ; swetha.rudraiah@uconn.edu" class="auth_mail" title="E-mail the corresponding author ; Xinsheng Gua ; gu.xinsheng@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ronald N. Hinesb ; hines.ronald@epa.gov" class="auth_mail" title="E-mail the corresponding author ; José ; E. Manautoua ; jose.manautou@uconn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：FMO3 ; Flavin-containing monoxygenase-3 ; NRF2 ; Nuclear factor (erythroid-derived 2)-like 2 ; KEAP1 ; Kelch-like ECH-associated protein 1 ; NQO1 ; NAD(P)H ; quinone oxidoreductase-1 ; HMOX1 ; heme oxygenase-1 ; tBHP ; tert-butyl hydroperoxide ; tBHQ ; tert-butyl hydroquinone
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：54-59
- 全文大小：809 K
文摘
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FMO3 gene expression by transcription factor NRF2 is investigated.
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NRF2 over-expression did not change FMO3 gene expression in HepG2 cells.
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NRF2 over-expression did not alter FMO3-directed reporter gene activity.
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20">NRF2 over-expression along with activation did not change reporter gene activity.
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25">FMO3 transcriptional regulation might not involve NRF2-KEAP1 regulatory pathway.