The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development
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- 作者：Larissa M. Williamsa ; b ; lwillia2@bates.edu" class="auth_mail" title="E-mail the corresponding author ; Briony A. Lagoc ; lagoba@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author ; Andrew G. McArthurc ; mcarthua@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author ; Amogelang R. Raphenyac ; raphenar@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author ; Nicholas Praya ; pray.nicholas@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nabil Saleema ; b ; nabilsaleem@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sophia Salasa ; b ; sophia.salas2@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Katherine Paulsona ; b ; krpaulson@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Roshni S. Mangarb ; d ; rmangar@coa.edu" class="auth_mail" title="E-mail the corresponding author ; Yang Liue ; yangliu0302@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Andy H. Voe ; Andy.Vo@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Jordan A. Shavite ; jshavit@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARE ; antioxidant response element ; bp ; base pair ; bZIP ; basic leucine zipper ; ChIP ; chromatin immunoprecipitation ; CNC ; Cap&rsquo ; n&rsquo ; Collar (CNC) ; hpe ; hours post exposure ; hpf ; hours post fertilization ; KO ; knockout ; NFE2 ; Nuclear Factor (Erythroid-Derived 2) ; NRF1 ; Nuclear Factor (Erythroid-Derived 2)-like 1 ; NRF2 ; Nuclear Factor (Erythroid-Derived 2)-like 2 ; NRF3 ; Nuclear Factor (Erythroid-Derived 2)-like 3 ; OSR ; oxidative stress response ; PBS ; phosphate buffered saline ; ROS ; reactive ox
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：180
- 期：Complete
- 页码：141-154
- 全文大小：3080 K
文摘
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Nfe2 is involved in erythropoiesis in zebrafish.
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Nfe2 is a novel regulator of pro-oxidant induced oxidative stress.
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Embryos mount a molecularly unique oxidative stress response compared to larvae.
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20">Nfe2 regulates a wide-variety of genes beyond erythropoiesis.