ESR1 mutations: Moving towards guiding treatment decision-making in metastatic breast cancer patients

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• 作者：Lindsay Angus ; ¹ ; ^{l.angus@erasmusmc.nl} ; Nick Beije¹ ; Agnes Jager ; John W.M. Martens ; Stefan Sleijfer
• 关键词：ESR1 mutations ; Metastatic breast cancer ; Endocrine resistance ; Cell-free DNA
• 刊名：Cancer Treatment Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：52
• 期：Complete
• 页码：33-40
• 全文大小：513 K
• 卷排序：52

文摘

Mutations in the ligand binding domain of ESR1 lead to ER constitutive activity. ESR1 mutations are associated with acquired endocrine resistance. Cell-free DNA is a good substrate for ESR1 mutation detection. ESR1 mutation analyses have great potential for clinical decision-making.