Maternal trans fat intake during pregnancy or lactation impairs memory and alters BDNF and TrkB levels in the hippocampus of adult offspring exposed to chronic mild stress

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• 作者：Camila Simonetti Pase^a ; ^b ; ^{camilapase@gmail.com} ; Karine Roversi^a ; Katiane Roversi^a ; Luciana Taschetto Vey^c ; Verô ; nica Tironi Dias^a ; Juliana Cristiana Veit^d ; Luana Haselein Maurer^d ; Thiago Duarte^a ; Tatiana Emanuelli^a ; ^d ; Marta Duarte^a ; ^e ; Marilise Escobar Bü ; rger^a ; ^c ; ^{mariliseescobar@gmail.com}
• 关键词：trans fatty acids ; Early developmental period ; Stress exposure ; Memory ; Neurotrophin ; Adult offspring
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：169
• 期：Complete
• 页码：114-123
• 全文大小：956 K
• 卷排序：169

文摘

Maternal nutrition in first stages of life is related to development of future adult. TFA in gestation and lactation caused memory impairments regardless of stress exposure. SO/FO and HVF supplementation in gestation increased BDNF expression after CMS exposure. Trans fatty in gestation and lactation periods showed decreased TrkB expression. Type of dietary FA in brain development period changes FA incorporation in brain.