DiiA is a novel dimorphic cell wall protein of Streptococcus pneumoniae involved in invasive disease
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- 作者：Marí ; a S. Escolano-Martí ; neza ; Arnau Domenechb ; c ; José ; Yustea ; b ; Marí ; a I. Cercenadoa ; Carmen Ardanuyb ; c ; Josefina Liñ ; aresb ; c ; Adela G. de la Campaa ; d ; Antonio J. Martin-Galianoa ; mgaliano@isciii.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adhesine ; Genomics ; Hypothetical protein ; Invasion ; Vaccine ; Virulence factor
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：73
- 期：1
- 页码：71-81
- 全文大小：1033 K
文摘
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DiiA is a new pneumococcal surface protein with a typical adhesine architecture.
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The diiA gene has two alleles with either one or two internal repeats.
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The long diiA allele is associated to invasive disease in patients.
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DiiA is involved in invasive disease in murine models.
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DiiA interacts to collagen and lactoferrin in vitro.