Metabolic profile of naringenin in the stomach and colon using liquid chromatography/electrospray ionization linear ion trap quadrupole-Orbitrap-mass spectrometry (LC-ESI-LTQ-Orbitrap-MS) and LC-ESI-MS/MS
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- 作者：Naiara Orrego-Lagaró ; na ; Anna Vallverdú ; -Queraltb ; c ; Miriam Martí ; nez-Hué ; lamoc ; d ; Rosa M. Lamuela-Raventosc ; d ; Elvira Escribano-Ferrera ; c ; eescribano@ub.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NAR ; naringenin ; LC-ESI-LTQ-Orbitrap-MS ; liquid chromatography coupled with an electrospray ionization hybrid linear ion trap quadrupole Orbitrap mass spectrometry technique ; LC-ESI-MS/MS ; liquid chromatography/electrospray ionization tandem mass spectrometry ; NAR-GLU ; naringenin-4 ; 7-O-glucuronide ; NAR-SULF ; naringenin-sulfate
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：20 February 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：38-45
- 全文大小：1276 K
文摘
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Provide new data about the metabolism of NAR while crossing the stomach and colon.
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Elucidate which metabolites may be responsible for biological effects attributed to NAR.
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Provide a wide metabolic profile of NAR by combining two analytical techniques.
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A LC-ESI-LQT-Orbitrab-MS enable us to accurately identify NAR metabolites.
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A LC-ESI-MS/MS enabled us to accurately idenfify and quantify NAR metabolites.