Hepatocellular carcinoma and lifestyles

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• 作者：Uttara Saran¹ ; ² ; Bostjan Humar³ ; Philippe Kolly¹ ; ² ; Jean-Franç ; ois Dufour¹ ; ² ; ^{jean-francois.dufour@insel.ch" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ACC ; acetyl coenzyme A carboxylase ; BMI ; body mass index ; DM ; diabetes mellitus ; FAS ; fatty acid synthase ; β-HAD ; β-hydroxyacyl-CoA dehydrogenase ; HBV ; hepatitis B virus ; HCC ; hepatocellular carcinoma ; HCV ; hepatitis C virus ; IHF ; intrahepatic fat ; MDA ; malondialdehyde ; NAFLD ; non-alcoholic fatty liver disease ; NASH ; non-alcoholic steatohepatitis ; FFA ; free fatty acids ; OLETF ; Otsuka Long-Evans Tokushima Fatty ; NEFA ; non-esterified fatty acids ; PA ; physical activity ; SCD-1 ; stearoyl-CoA desatura
• 刊名：Journal of Hepatology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：64
• 期：1
• 页码：203-214
• 全文大小：5616 K

文摘

The majority of hepatocellular carcinoma occurs over pre-existing chronic liver diseases that share cirrhosis as an endpoint. In the last decade, a strong association between lifestyle and hepatocellular carcinoma has become evident. Abundance of energy-rich food and sedentary lifestyles have caused metabolic conditions such as obesity and diabetes mellitus to become global epidemics. Obesity and diabetes mellitus are both tightly linked to non-alcoholic fatty liver disease and also increase hepatocellular carcinoma risk independent of cirrhosis. Emerging data suggest that physical activity not only counteracts obesity, diabetes mellitus and non-alcoholic fatty liver disease, but also reduces cancer risk. Physical activity exerts significant anticancer effects in the absence of metabolic disorders. Here, we present a systematic review on lifestyles and hepatocellular carcinoma.