Estrogen receptors modulate striatal metabotropic receptor type 5 in intact and MPTP male mice model of Parkinson’s disease
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- 作者：S. Al-Sweidia ; b ; M. Morissettea ; T. Di Paoloa ; b ; therese.dipaolo@crchul.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：A ; adenosine ; DA ; dopamine ; CNS ; central nervous system ; CREB ; cAMP response element-binding protein ; DAT ; dopamine transporter ; ERK ; extracellular signal-regulated kinase ; ER ; estrogen receptor ; ERKO ; estrogen receptor knock out ; L-DOPA ; levodopa ; MAPK ; mitogen-activated protein kinase ; mGlu ; metabotropic glutamate ; MPEP ; [2-methyl-6-(phenylethynyl)pyridine ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; MTEP ; 3-[(2-methyl-1 ; 3-thiazol-4-yl)ethynyl] pyridine ; PD ; Parkinson&rsquo ; s disease
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：84-91
- 全文大小：1357 K
文摘
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mGlu5 receptor specific binding is lower in dorsal compared to ventral striatum.
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mGlu5 receptor specific binding is similar in lateral compared to medial striatum.
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Striatal mGlu5 receptor binding is lower in ERKOα and ERKOβ compared to WT mice.
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Striatal mGlu5 receptor binding decreases in MPTP WT but not in ERKOα and ERKOβ mice.
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Estradiol modulates striatal mGlu5 receptors and BDNF in MPTP WT but not ERKO (α or β) mice.
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