Cells redox environment modulates BRCA1 expression and DNA homologous recombination repair
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- 作者：Aaron Wilson ; Vasily A. Yakovlev ; vasily.yakovlev@vcuhealth.org
- 关键词：bp ; base pairs ; BRCA1 ; breast cancer type 1 susceptibility protein ; CO3&bull ; &minus ; carbonate ; DETA ; DETA NONOate ; DSB ; double strand break ; EtBr ; ethidium bromide ; ETC ; electron transport chain ; FAD ; flavin adenine dinucleotide ; FADH ; reduced flavin adenine dinucleotide ; GFP ; green fluorescent protein ; HE ; dihydroethidium ; HRR ; homologous recombination repair ; IFU ; infectious units ; mtDNA ; mitochondrial DNA ; NAD ; nicotinamide adenine dinucleotide ; NADH ; reduced nicotinamide adenine dinucleot
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：190-201
- 全文大小：2357 K
- 卷排序：101
文摘
An increase of oxidizing condition of cells stimulates PP2A activity. Activated PP2A inhibits BRCA1 expression through the RBL2/E2F4-dependent mechanism. Inhibition of BRCA1 expression significantly reduces the high-fidelity DNA HRR. Reduced DNA HRR maintains genomic instability essential for tumor progression.