Both ethanol and protein deficiency increase messenger RNA levels for pancreatic lithostathine

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• 作者：Korsten ; Mark A. ; Wilson ; Jeremy S. ; Apte ; Minoti V. ; Norton ; Ian D. ; Haber ; Paul S. ; McCaughan ; Geoffrey W. ; et. al.
• 关键词：ethanol ; protein deficiency ; pancreatitis ; lithostathine
• 刊名：Life Sciences
• 出版年：1996
• 出版时间：January 5, 1996
• 年：1996
• 卷：58
• 期：6
• 页码：485-492
• 全文大小：582 K

文摘

Both ethanol abuse and protein deficiency are well known associations of chromic pancreatitis. An early event in chronic pancreatitis is the deposition of protein plugs in small pancreatic ducts, leading to ductular obstruction and acinar cell damage. Lithostathine, a pancreatic secretory protein, is a major organic component of protein plugs. The aim of this study was to determine the effect of chronic ethanol administration and dietary protein deficiency, separately and in combination, on messenger RNA (mRNA) levels for pancreatic lithostathine. Male Sprague-Dawley rats were fed in groups of four, for four weeks, protein sufficient and protein deficient diets with or without ethanol. Messenger RNA levels for pancreatic lithostathine were assessed in all four groups. Both ethanol and protein deficiency, separately and in combination, increased mRNA levels for lithostathine. Thus, both chronic ethanol consumption and dietary protein deficiency increase the capacity of the pancreatic acinar cell to synthesize lithostathine.