Effect of organic co-solvents in the evaluation of the hydroxyl radical scavenging activity by the 2-deoxyribose degradation assay: The paradigmatic case of α-lipoic acid

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• 作者：Andrea Brizzolari^a ; Giuseppe M. Campisi^a ; Enzo Santaniello^a ; ¹ ; Nima Razzaghi-Asl^b ; Luciano Saso^c ; Mario C. Foti^d ; ^{mario.foti@cnr.it}
• 关键词：2-DR ; 2-deoxyribose ; DMF ; dimethylformamide ; DMSO ; dimethylsulfoxide ; EDTA ; ethylenediaminetetraacetic acid ; LA ; (R ; S)-lipoic acid ; MDA ; malondialdehyde ; ROS ; reactive oxygen species ; TBA ; thiobarbituric acid
• 刊名：Biophysical Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：220
• 期：Complete
• 页码：1-6
• 全文大小：887 K
• 卷排序：220

文摘

Use of the 2-deoxyribose assay with molecules poorly soluble in water Surprisingly low reactivity of acetonitrile toward the HO radical Polar transition state for the H-atom abstraction from hydrocarbons by HO